WE’RE MAKING OUR MARK BY BARELY LEAVING ONE
BIOVANCE is decellularized, dehydrated human amniotic membrane (DDHAM) derived from the placenta of a healthy, full-term pregnancy.
BIOVANCE Is Unique
BIOVANCE is unique because it is prepared from the amnion—the part of the amniotic sac closest to the developing embryo. The amnion is excised from the chorion layer of the placenta, washed, and then sterilized so that it contains only what’s needed.
The natural properties of the amniotic membrane support the growth and development of the baby. For 9 months, the amniotic membrane:
- Forms the innermost lining of the placenta during gestation1
- Is the tissue closest to the baby throughout development
- Serves as a barrier to minimize risk of injury to the baby1-3
BIOVANCE® is a decellularized, dehydrated human amniotic membrane (DDHAM) with a preserved natural epithelial basement membrane and an intact extracellular matrix structure. The epithelial basement membrane and extracellular matrix of this allograft provide a natural scaffold. BIOVANCE provides a protective cover from the surrounding environment.
- Collagen I, II, III, IV
See BIOVANCE in Action
Watch a brief video animation that illustrates the mechanism of action of BIOVANCE.
Easy to Use
BIOVANCE is easy to use, making it ideal for surgical and nonsurgical settings.
Easy to apply
- No preparation needed – No thawing, rinsing, or soaking required prior to use
- Flexible form – Conforms easily to irregular surfaces; can be wrapped around tendons or placed between adjacent tissues
- Bidirectional orientation – Prevents the need for specific placement of BIOVANCE on the wound; can be applied with either side facing the wound
- Adheres without sutures – Can be fastened by all surgical means if physician chooses to do so
- Ambient room-temperature storage in a clean, dry environment – No refrigeration necessary
- 10-year shelf life – Eliminates the need for preordering
Immunologically Inert Tissue
BIOVANCE is immunologically inert tissue that has been minimally processed.
- BIOVANCE contains no antigens7
- Tissue derived from the amniotic membrane is cleaned and preserved without altering its native matrix architecture
Additional safety features
Tissue used in processing BIOVANCE:
- Has been procured, processed, and tested in accordance with standards established by the American Association of Blood Banks (AABB) and the United States Food and Drug Administration (FDA)
- Passed safety testing for cytotoxicity, hemolysis, irritation, endotoxins, and pyrogenicity
- Utilizes a barcode tracking system for optimal safety monitoring and to enhance patient and practitioner confidence
Available in 8 different sizes for application flexibility (10x10cm coming soon)
Product Code DHAM0012
Product Code DHAM0022
Product Code DHAM0023
Product Code DHAM0024
Product Code DHAM0035
Product Code DHAM0044
Product Code DHAM0055
Product Code DHAM0066
Clinical Outcomes Gallery
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- Fetterolf DE, Synder RJ. Scientific and clinical support for the use of dehydrated amniotic membrane in wound management. Wounds. 2012;24(10):299-307.
- Bhatia M, Pereira M, Rana H, et al. Mechanism of cell interaction and response on decellularized human amniotic membrane: implications in wound healing. Wounds. 2007;19(8):207-217.
- Arechavaleta-Velasco F, Marciano D, Díaz-Cueto L, Parry S. Matrix metalloproteinase-8 is expressed in human chorion during labor. Am J Obstet Gynecol. 2004;190(3):843-850.
- Faulk WP, Matthews R, Stevens PJ, et al. Human amnion as an adjunct in wound healing. Lancet. 1980;1(8179):1156-1158.
- Ganatra MA. Amniotic membrane in surgery. J Pak Med A. 2003;53(1):29-32.
- Portmann-Lanz CB, Ochsenbein-Kölble N, Marquardt K, et al. Manufacture of a cell-free amnion matrix scaffold that supports amnion cell outgrowth in vitro. Placenta. 2007;28(1):6-13.
- Niknejad H, Peirovl H, Jorjani M, et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cell Mater. 2008;15:88-99.