About BIOVANCE®

WE’RE MAKING OUR MARK BY BARELY LEAVING ONE

BIOVANCE is decellularized, dehydrated human amniotic membrane (DDHAM) derived from the placenta of a healthy, full-term pregnancy.

BIOVANCE Is Unique

BIOVANCE is unique because it is prepared from the amnion—the part of the amniotic sac closest to the developing embryo. The amnion is excised from the chorion layer of the placenta, washed, and then sterilized so that it contains only what’s needed.

The natural properties of the amniotic membrane support the growth and development of the baby. For 9 months, the amniotic membrane:

Forms the innermost lining of the placenta during gestation¹
Is the tissue closest to the baby throughout development
Serves as a barrier to minimize risk of injury to the baby^1-3

BIOVANCE® is a decellularized, dehydrated human amniotic membrane (DDHAM) with a preserved natural epithelial basement membrane and an intact extracellular matrix structure. The epithelial basement membrane and extracellular matrix of this allograft provide a natural scaffold. BIOVANCE provides a protective cover from the surrounding environment.

BIOVANCE components

Collagen I, II, III, IV
Elastin
Glycosaminoglycans
Fibronectin
Laminin
Proteoglycans

See BIOVANCE in Action

Watch a brief video animation that illustrates the mechanism of action of BIOVANCE.

Translucent grid pattern on the BIOVANCE allograft is evident on the wound until hydration occurs to allow view of the wound’s progress.

Easy to Use

BIOVANCE is easy to use, making it ideal for surgical and nonsurgical settings.

Easy to apply

No preparation needed – No thawing, rinsing, or soaking required prior to use
Flexible form – Conforms easily to irregular surfaces; can be wrapped around tendons or placed between adjacent tissues
Bidirectional orientation – Prevents the need for specific placement of BIOVANCE on the wound; can be applied with either side facing the wound
Adheres without sutures – Can be fastened by all surgical means if physician chooses to do so

Convenient storage

Ambient room-temperature storage in a clean, dry environment – No refrigeration necessary
10-year shelf life – Eliminates the need for preordering

Immunologically Inert Tissue

BIOVANCE is immunologically inert tissue that has been minimally processed.

BIOVANCE contains no antigens⁷
Tissue derived from the amniotic membrane is cleaned and preserved without altering its native matrix architecture

Additional safety features

Tissue used in processing BIOVANCE:

Has been procured, processed, and tested in accordance with standards established by the American Association of Blood Banks (AABB) and the United States Food and Drug Administration (FDA)
Passed safety testing for cytotoxicity, hemolysis, irritation, endotoxins, and pyrogenicity
Utilizes a barcode tracking system for optimal safety monitoring and to enhance patient and practitioner confidence

Available in 8 different sizes for application flexibility (10x10cm coming soon)

1×2 cm
Product Code DHAM0012

2×2 cm
Product Code DHAM0022

2×3 cm
Product Code DHAM0023

2×4 cm
Product Code DHAM0024

3×3.5 cm
Product Code DHAM0035

4×4 cm
Product Code DHAM0044

5×5 cm
Product Code DHAM0055

6×6 cm
Product Code DHAM0066

10×10 cm
Coming Soon

Clinical Outcomes Gallery

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References:

Fetterolf DE, Synder RJ. Scientific and clinical support for the use of dehydrated amniotic membrane in wound management. Wounds. 2012;24(10):299-307.
Bhatia M, Pereira M, Rana H, et al. Mechanism of cell interaction and response on decellularized human amniotic membrane: implications in wound healing. Wounds. 2007;19(8):207-217.
Arechavaleta-Velasco F, Marciano D, Díaz-Cueto L, Parry S. Matrix metalloproteinase-8 is expressed in human chorion during labor. Am J Obstet Gynecol. 2004;190(3):843-850.
Faulk WP, Matthews R, Stevens PJ, et al. Human amnion as an adjunct in wound healing. Lancet. 1980;1(8179):1156-1158.
Ganatra MA. Amniotic membrane in surgery. J Pak Med A. 2003;53(1):29-32.
Portmann-Lanz CB, Ochsenbein-Kölble N, Marquardt K, et al. Manufacture of a cell-free amnion matrix scaffold that supports amnion cell outgrowth in vitro. Placenta. 2007;28(1):6-13.
Niknejad H, Peirovl H, Jorjani M, et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cell Mater. 2008;15:88-99.